Characterization of Influenza Viruses-China, 2019−2020

作     者：Weijuan Huang Yanhui Cheng Tao Chen Xiyan Li Minju Tan Hejiang Wei Xiaoxu Zeng Yiran Xie Jia Liu Ning Xiao Lei Yang Dayan Wang 

作者机构：National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionWHO Collaborating Center for Reference and Research on InfluenzaKey Laboratory for Medical VirologyNational Health CommissionBeijingChina 

出 版 物：《China CDC weekly》 (中国疾病预防控制中心周报（英文）)

年 卷 期：2020年第2卷第44期

页      面：856-861页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

主　　题：epidemiology prevention mainland 

摘      要：Introduction:Influenza surveillance is necessary for detection of emerging variants of influenza viruses and determining their epidemiological and clinical *** and antiviral drugs remain the most useful ways to protect against seasonal influenza and its potentially severe *** study describes the epidemiology,antigenic and genetic characteristics,and antiviral susceptibilities of influenza viruses isolated from the mainland of China during the April 1,2019 through October 4,***:All viruses analyzed were isolated and submitted by Chinese National Influenza Surveillance Network *** Chinese National Influenza Center performed antigenic analysis,sequencing,and antiviral resistance testing after propagation of the *** characterizations were determined by hemagglutinin inhibition assay;next-generation sequencing was used for genetic analyses;phenotypic assay and next-generation sequencing were used for determining antiviral ***:The influenza positivity rate declined significantly starting in late January 2020 and has remained *** was no summer influenza peak season in south *** A(H3N2)and B/Victoria lineage viruses were the dominant subtype/lineage during April 1,2019 through October 4,*** majority of influenza viruses were antigenically and genetically similar to reference viruses representing components of vaccines for the 2020–2021 northern hemisphere influenza *** all seasonal influenza viruses were susceptible to oseltamivir and *** and Implications for Public Health Practice:Since the outbreak of COVID-19,the influenza positivity rate declined with implementation of strong COVID-19 control *** majority of circulating viruses are well matched with the current 2020–2021 northern hemisphere influenza vaccine *** seasonal influenza viruses were sensitive to neuraminidase inhibitors and Baloxavir *** st