Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2

作     者：Dan Zhao Weifan Xu Xiaofan Zhang Xiaoting Wang Yiyue Ge Enming Yuan Yuanpeng Xiong Shenyang Wu Shuya Li Nian Wu Tingzhong Tian Xiaolong Feng Hantao Shu Peng Lang Jingxin Li Fengcai Zhu Xiaokun Shen Haitao Li Pilong Li Jianyang Zeng Dan Zhao;Weifan Xu;Xiaofan Zhang;Xiaoting Wang;Yiyue Ge;Enming Yuan;Yuanpeng Xiong;Shenyang Wu;Shuya Li;Nian Wu;Tingzhong Tian;Xiaolong Feng;Hantao Shu;Peng Lang;Jingxin Li;Fengcai Zhu;Xiaokun Shen;Haitao Li;Pilong Li;Jianyang Zeng

作者机构：Institute for Interdisciplinary Information SciencesTsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Structural Biology Frontier Research Center for Biological StructureSchool of Life SciencesTsinghua UniversityBeijing 100084China Winghua-Peking Center for Life SciencesTsinghua UniversityBeijing 100084China Silexon Al Technology Co.LtdNanjing 210033China NHC Key Laboratory of Enteric Pathogenic MicrobiologyJiangsu Provincial Center for Diseases Control and PreventionNanjing 210009China Bioinformatics DivisionBNRIST/Department of Computer Science and TechnologyTsinghua UniversityBeijing 100084China Protein Preparation and Identification FacilityTechnology Center for Protein ScienceTsinghua UniversityBeijing 100084China Institute of PathologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China Center for Global HealthNanjing Medical UniversityNanjing 210009China Convalife(Shanghai)Co.LtdShanghai 201203China Ministry of Education Key Laboratory of Protein SciencesBeijing Advaneed Innovation Center for Structural BiologyBeijing Frontier Research Center for Biological StructureDepartment of Basic Medical SciencesSchool of MedicineTsinghua UniversityBeijing 100084China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2021年第12卷第9期

页      面：734-740页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 10[医学] 

基　　金：This work was supported in part by the National Natural Science Foundation of China(61872216 and 81630103 to JZ,31900862 to DZ,31871443 to PL) the National Key R&D Program(2019YFA0508403 to PL,2020YFA0803300 to HL) the Turing Al Institute of Nanjing and the Zhongguancun Haihua Institute for Frontier Information Technology. 

主　　题：respiratory acute therapeutic 

摘      要：Dear Editor To date,tens of millions of people have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),causing the outbreak of the respiratory disease named the coronavirus disease 2019(COVID-19).As a newly emerged member of the coronavirus family,SARS-CoV-2 is an enveloped positive-strand RNA virus,which has probably the largest genome(approximately 30 kb)among all RNA viruses.The nucleocapsid(N)protein of SARS-CoV-2 is mainly responsible for recognizing and wrapping viral RNA into helically symmetric structures(Malik,2020).