Is there a standardized practice for the development of international ulcerative colitis and Crohn’s disease treatment guidelines?

作     者：Alexander Goldowsky Rohan Sen Gila Hoffman Joseph D Feuerstein 

作者机构：Department of MedicineBeth Israel Deaconess Medical CenterBostonMAUSA Department of Gastroenterology and HepatologyBeth Israel Deaconess Medical CenterBostonMAUSA 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2021年第9卷第5期

页      面：408-417,I0001,I0002页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Crohn’s disease ulcerative colitis inflammatory bowel disease guidelines conflicts of interest 

摘      要：Background Guidelines are published by international gastroenterology societies regarding the management of ulcerative colitis(UC)and Crohn’s disease(CD)to help clinicians to provide high-quality patient *** examined the guidelines for the quality and strength of evidence used to develop the recommendations,methods for grading evidence,differences in disease-specific recommendations,conflicts of interest,and plans for guideline *** A systematic search was performed on PubMed using“ulcerative colitis,“Crohn’s disease,and“guidelinesin April *** gastroenterology society websites were searched for UC-and CD-specific *** from 12 societies were examined by two ***-squared tests were used for comparing evidence-level grades,strength of recommendations,and reported conflicts of ***-regression modeling was used to evaluate the relationship between the number of authors and the number of recommendations in a given *** Of 28 guidelines reviewed,25(89%)used a total of three different systems to grade the level of evidence and 2(7%)used an unknown ***(11%)reviewed guidelines did not provide a conflict-of-interest statement,while three(11%)provided a timeline for guideline *** 1,265 total statements examined,246(19%)reported no grade of evidence quality or explicitly stated that the recommendation was based on“expert opinion.One hundred and thirty-five(22%)UC recommendations were noted to be“weak/conditionaland 95(16%)did not have a recommendation *** hundred and forty-two(37%)CD recommendations were noted to be“weak/conditionaland 151(23%)did not have a recommendation *** The majority of UC and CD guidelines are based on a low/very low quality of evidence and are further weakened due to the lack of homogeneity in specific aspects of management recommendations as well as conflicts of interest.