Differential Expressing of Centromere Protein CenpG in Breast Cancer

作     者：梁前进 Lu Xiangfeng Cheng Xiaolei Zhang Huanxiang He Dacheng WANG Yongchao 

作者机构：College of Life Sciences Beijing Normal University Beijing 100875 P.R.China Dongzhimen Hospital of Beijing University of Chinese Traditional Medicine Beijing 100700 P.R.China Tayuan Hospital of Beijing Red Cross Beijing 100083 China. Zhang Huanxiang 

出 版 物：《High Technology Letters》 (高技术通讯（英文版）)

年 卷 期：2002年第8卷第1期

页      面：1-4页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：thefundsofStateMa jorBasicResearchDevelopmentProject ("97.3"Project)ofChina(No .G19990 5 390 1)andtheNationalNaturalScienceFoundationofChina(No .39430 0 80and 39970 36 1) 

主　　题：Breast cancer Centromere protein CenpG 

摘      要：Using indirect immunofluorescence (IIF), an anti-centromere protein CenpG-serum was verified. Western blot of the protein extracts of 31 samples of breast cancer tissues and their normal (not cancerous ) tissues a little far away from them in the same individuals showed that, in the majority of the tests (71%), centromere protein CenpG over expressed in breast cancer tissues. And moreover, a kind of protein component whose molecular weight is 43 kd, and which can be recognized by anti-CenpG serum was found in two of the cancer samples. The results suggested that CenpG (together whith it, there may be other relative components),which has been found and named recently, may be related to cancer,and its differential expressing is probably related to malignant cell proliferation.