N,O-Bis(trimethylsilyl)acetamide/N-hydroxysuccinimide ester(BSA/NHS) as coupling agents for dipeptide synthesis

作     者：Ye Huang Wen-Hua Feng 

作者机构：Department of New Drug Research and DevelopmentInstitute of Materia Medica & Peking Union Medical CollegeChinese Academy of Medical Sciences 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2016年第27卷第3期

页      面：357-360页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：financially supported by the National Science and Technology Major Project of China(No.521042) 

主　　题：Dipeptide synthesis Solution-phase N O-Bis(trimethylsilyl)acetamide N-Hydroxysuccinimide ester Water washing 

摘      要：A method using N,O-bis（trimethylsilyl）acetamide/N-hydroxysuccinimide ester（BSA/NHS） as coupling agents for dipeptide synthesis is descried. The coupling reaction between N-hydroxysuccinimide（NHS）esters and amines could be performed under mild conditions with N,O-bis（trimethylsilyl）acetamide（BSA） as coupling reagent and no additional acid/base is required. All byproducts and excessive reactants are water soluble or hydrolysable and easy to eliminate through water-washing at the purification ***, all the reactants are inexpensive and widely used in conventional drug production.