Endoscopic radiofrequency ablation for malignant biliary obstruction
作者机构：Department of Gastroenterology and HepatologyInstitute for Clinical and Experimental MedicinePraha 14021Czech Republic Department of Internal Medicine II–Gastroenterology and GeriatricsUniversity Hospital OlomoucFaculty of Medicine and DentristryPalacky University OlomoucOlomouc 77900Czech Republic
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第10期
页 面：1383-1396页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：The Czech Grant Research Council No.17-30281A
主 题：Radiofrequency Ablation Biliary Stenosis Cholangiocarcinoma Pancreatic cancer
摘 要：Cholangiocarcinoma and pancreatic cancer are the most common causes of malignant biliary *** majority of patients are diagnosed at a late stage when surgical resection is rarely *** these cases,palliative chemotherapy and radiotherapy provide only limited benefit and are associated with poor *** ablation(RFA)is a procedure for locoregional control of tumours,whereby a high-frequency alternating current turned into thermal energy causes coagulative necrosis of the tissue surrounding the *** subsequent release of debris and tumour antigens by necrotic cells can stimulate local and systemic *** development of endoluminal RFA catheters has led to the emergence of endoscopically delivered RFA,a treatment mainly used for malignant biliary strictures to prolong survival and/or stent *** indications include recanalisation of occluded biliary stents and treatment of intraductal ampullary adenoma or benign biliary *** article presents a comprehensive review of endobiliary RFA,mainly focusing on its use in patients with malignant biliary *** available data suggest that biliary RFA may be a promising modality,having positive impacts on survival and stent patency and boasting a reasonable safety ***,further studies with better characterised and stratified patient populations are needed before the method becomes accepted within routine clinical practice.
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