Iron-Catalyzed Borylation and Silylation of Unactivated Tertiary,Secondary,and Primary Alkyl Chlorides

作     者：Siyu Wang Minghui Sun Huan Zhang Juan Zhang Yun He Zhang Feng 

作者机构：Chongqing Key Laboratory of Natural Product Synthesis and Drug ResearchSchool of Pharmaceutical SciencesChongqing UniversityChongqing 401331 Sichuan Key Laboratory of Medical ImagingDepartment of ChemistrySchool of Preclinical MedicineNorth Sichuan Medical CollegeSichuan 637000 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2021年第3卷第9期

页      面：2164-2173页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：support from the National Natural Science Foundation of China(no.21801029) the Fundamental Research Funds for the Central Universities(no.2020CDJQY-A043) the Sichuan Key Laboratory of Medical Imaging(North Sichuan Medical College,no.SKLMI201901) the Strategic Cooperation of Science and Technology between Nanchong City and North Sichuan Medical College(nos.19SXHZ0441 and 19SXHZ0227) the Chongqing Postdoctoral Science Foundation(no.cstc2020jcyj-bsh0061) the China Postdoctoral Science Foundation(no.2020M673121) the Natural Science Foundation of Chongqing(no.cstc2019jcyj-msxmX0048) 

主　　题：iron catalysis borylation silylation unactivated alkyl chlorides 

摘      要：Herein,we describe an iron-catalyzed borylation and silylation of unactivated alkyl chlorides,delivering the tertiary,secondary,and primary alkylboronic esters,and secondary,primary alkylsilanes with high *** protocol exhibits broad substrate scope and good functional group compatibility,allowing the efficient late-stage borylation of biorelevant compounds,thus offering an excellent platform in drug discovery and *** mechanistic studies suggest that an alkyl radical was involved in this catalytic system.