Recent progress in research and application of engineered implanted cells for biomedical applications

作     者：Tianying Chen Xue Zhang Qiong Wu Tianying Chen;Xue Zhang;Qiong Wu

作者机构：MOE Key Laboratory of BioinformaticsSchool of Life SciencesTsinghua UniversityBeijing 100084China Center for Synthetic and Systems BiologyTsinghua UniversityBeijing 100084China 

出 版 物：《Quantitative Biology》 (定量生物学（英文版）)

年 卷 期：2021年第9卷第3期

页      面：267-291页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：This work was financially supported by National Key Research and Development Project of China(No.2018YFA0900100) the National Natural Science Foundation of China(No.31961133019) National Natural Science Foundation of China(No.31670091) The National Natural Science Foundation of China(No.31961133019)is part of MIX-UP,a joint NSFC and EU H2020 collaboration In Europe,MIX-UP has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 870294 

主　　题：chassis cells cell therapy engineered implanted cells synthetic biology 

摘      要：Background:The core concept of cell engineering is the use of synthetic biological methods to engineer and design genetically modified cells with specific functions,which has revolutionized the biotechnology industry and cell *** cells play an important role in the cell therapy,but the currently used implanted cells are unable to fully meet the needs of researchers and ***,the construction of engineered implanted cells has become a new research area,with many groups exploring the working principles of implanted cells,allowing them to better exert their repair ***:Based on the existing cell engineering platforms,this paper summarizes the main types of chassis cells used in implanted cell engineering,progress in the development of gene editing tools and delivery systems,as well as strategies for the construction of engineered implanted ***:The rational use of synthetic biology methods to program and control the function of implanted cells with high spatiotemporal accuracy provides new ideas for the development of cell therapy,and opens up new possibilities for exploring the mechanism of implanted cell action to allow them to better exert their role in promoting the progress of repair.