Cyclic and Linear Thiopeptides from Soil-Derived Streptomyces *** 203702 with Antiviral and Antibacterial Activities
作者机构：Division for Medicinal Microorganisms Related Strains CAMS Collection Center of Pathogenic MicroorganismsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China College of Health and EnvironmentBeijing Union UniversityBeijing 100023China School of PharmacyYantai UniversityYantaiShangdong 264005China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2021年第39卷第12期
页 面：3277-3284页
核心收录：
学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学]
基 金：This work was financially supported by the National Natural Science Foundation of China(Nos.82073744 and 81402835) CAMS Initiative for Innovative Medicine(Nos.2020-I2M-2-010 and CAMS-I2M-3-014) the National Mega-project for Innovative Drugs(Nos.2019ZX09721001-004-006 and 2018ZX09711001-007-001) the National Microbial Resource Center(No.NMRC-2020-3)
主 题：Thiopeptide Streptomyces Natural products Structure elucidation Antiviral agents
摘 要：A new cyclic thiopeptide,berninamycin F(3),three new linear thiopeptides,berninamycins G—I(4-6),and two known berninamycin derivatives,berninamycins C and D(1 and 2)were isolated from Streptomyces *** *** structures were elucidated through HRESIMS and one-and two-dimensional NMR data,and the absolute configurations were assigned using Marfey s *** 4-6 are the first examples of linear berninamycin ***,compound 4 is the first example of linear thiopeptide with a 1-(oxazol-2-yl)ethan-1-one group,compound 6 is the first linear thiopeptide derivative with methylated oxoacetate *** 1-6 exhibited excellent anti-Zika virus activities with IC_(50) values in the range of 4.4-10.5μmol/L,which were superior to that of the positive control ribavirin(IC_(50)=49.2μmol/L).Compounds 1 and 3 showed strong anti-influenza A virus activities with the IC_(50) values of 15.6 and 3.2μmol/L,*** 1 exhibited good antibacterial activities against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus ***.
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