Multi-Omics and Its Clinical Application in Hepatocellular Carcinoma:Current Progress and Future Opportunities

作     者：Wanshui Yang Hanyu Jiang Chao Liu Jingwei Wei Yu Zhou Pengyun Gong Bin Song Jie Tian 杨万水;蒋涵羽;刘超;魏靖伟;周宇;宫鹏云;宋彬;田捷

作者机构：Department of NutritionSchool of Public HealthAnhui Medical UniversityHefei 230032China Department of RadiologyWest China HospitalSichuan UniversityChengdu 610041China Beijing Advanced Innovation Center for Big Data-Based Precision MedicineSchool of Medicine and EngineeringBeihang UniversityBeijing 100191China Key Laboratory of Big Data-Based Precision Medicine(Beihang University)Ministry of Industry and Information TechnologyBeijing 100191China Key Laboratory of Molecular ImagingInstitute of AutomationChinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of Molecular ImagingBeijing 100190China University of Chinese Academy of SciencesBeijing 100049China School of Life Science and TechnologyXidian UniversityXi'an 710126China Engineering Research Center of Molecular and Neuro Imaging of Ministry of EducationSchool of Life Science and TechnologyXidian UniversityXi'an 710126China 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：2021年第36卷第3期

页      面：173-186页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：hepatocellular carcinoma radiomics proteomics genomics multi-omics 

摘      要：Hepatocellular carcinoma(HCC)is the sixth most common malignancy and the fourth leading cause of cancer related death *** covers over half of cases,leading HCC to be a vital threaten to public *** advances in diagnosis and treatments,high recurrence rate remains a major obstacle in HCC ***-omics currently facilitates surveillance,precise diagnosis,and personalized treatment decision making in clinical ***-invasive radiomics utilizes preoperative radiological imaging to reflect subtle pixel-level pattern changes that correlate to specific clinical *** has been widely used in histopathological diagnosis prediction,treatment response evaluation,and prognosis ***-throughput sequencing and gene expression profiling enabled genomics and proteomics to identify distinct transcriptomic subclasses and recurrent genetic alterations in HCC,which would reveal the complex multistep process of the *** accumulation of big medical data and the development of artificial intelligence techniques are providing new insights for our better understanding of the mechanism of HCC via multi-omics,and show potential to convert surgical/intervention treatment into an antitumorigenic one,which would greatly advance precision medicine in HCC management.