Novel chimeric antigen receptor T cells based on T-cell receptor-like antibodies

作     者：Qi Zhao Zhao Qi

作者机构：Institute of Translational MedicineCancer CentreBiological Imaging&Stem Cell CoreFaculty of Health SciencesUniversity of MacaoTaipaMacao SPRChina 

出 版 物：《Blood Science》 (血液科学（英文）)

年 卷 期：2019年第1卷第2期

页      面：144-147页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：support from the Science and Technology Development Fund,Macao SAR(File No.FDCT/131/2016/A3,FDCT/0015/2018/A1) the Guangzhou Science and Technology Program(201807010004) the Multi-Year Research Grant(File No.MYRG2019-00069-FHS) Start-up Research Grand(File No.SRG2016-00082-FHS) the intramural research program of Faculty of Health Sciences,University of Macao. 

主　　题：Antibody CAR T cell TCR-like antibody 

摘      要：The need for novel therapeutics against human cancers such as leukemias and solid tumors is well recognized.Human T cells are poised to make a fundamental change in the therapeutic approach.T-cell interaction with a tumor cell is a critical event and primarily driven by T-cell receptor(TCR)recognition of peptide in the pocket HLA.However,among TCR-based T-cell therapies,either TCR mismatching or the low density of major histocompatibility complex causes tumor cells to escape from the immune response.TCR molecules have low binding affinities,preventing their recognitions.Undoubtedly,antibody therapeutics is an effective treatment for cancer.As the new generation of monoclonal antibodies,TCR-like antibodies can mimic TCR recognition but are not susceptible for mechanisms of tumor evasion from the immune response.As chimeric antigen receptor(CAR)structure expressed on the surface of T cells,TCR-like antibodies can confer antigen specificity to T cells.The new TCR-like CAR may be important to drive new technologies of adoptive cell therapy,in particular,T-cell therapy,and open possibilities to target endogenous tumor-specific antigens.