Calmodulin modulation of ion channels and receptors

作     者：DONG Xianping, ZHI Gang and XU Tianle( School of Life Sciences, University of Science and Technology of China, Hefei 230027, China The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA) 

出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))

年 卷 期：2002年第4期

页      面：3-10页

学科分类：0710[理学-生物学] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：Supported by the National Natural Science Foundation of China (Grant Nos. 39770248, 39970200) the Knowledge Innovation Project of the Chinese Academy of Sciences 

主　　题：calmodulin receptor ion channel inactivation facilitation. 

摘      要：Ion channels and receptors are the structural basis for neural signaling and transmission. Recently, the function of ion channels and receptors has been demonstrated to be modulated by many intracellular and extracellular chemicals and signaling molecules. Increasing evidence indicates that the complexity and plasticity of the function of central nervous system is determined by the modulation of ion channels and receptors. Among various mechanisms, Ca2 + signaling pathways play important roles in neuronal activity and some pathological changes. Ca2+ influx through ion channels and receptors can modulate its further influx in a feedback way or modulate other ion channels and receptors. The common feature of the modulation is that Ca2 + /calmodulin (CaM) is the universal mediator. CaM maintains the coordination among ion channels/receptors and intracellular Ca2+ homeostasis by feedback modulation of ion channels/receptors activity. This review focuses on the modulating processes of ion channels and recept