Recent progress on betulinic acid and its derivatives as antitumor agents:a mini review

作     者：ZHONG Ye LIANG Nan LIU Yang CHENG Mao-Sheng ZHONG Ye;LIANG Nan;LIU Yang;CHENG Mao-Sheng

作者机构：Key Laboratory of Structure-Based Drug Design&Discovery of Ministry of EducationSchool of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang 110016China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2021年第19卷第9期

页      面：641-647页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 0703[理学-化学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：supported by the National Natural Science Foundation of China(Nos.20472054 30772641 30973613 21142010 and 81473087)。 

主　　题：Betulinic acid Natural products Structural modification Derivatives Antitumor activity 

摘      要：Natural products are one of the important sources for the discovery of new drugs.Betulinic acid(BA),a pentacyclic triterpenoid widely distributed in the plant kingdom,exhibits powerful biological effects,including antitumor activity against various types of cancer cells.A considerable number of BA derivatives have been designed and prepared to remove their disadvantages,such as poor water solubility and low bioavailability.This review summarizes the current studies of the structural diversity of antitumor BA derivatives within the last five years,which provides prospects for further research on the structural modification of betulinic acid.