Histone methylation in pancreatic cancer and its clinical implications
作者机构：The First Hospital of Jilin UniversityJilin UniversityChangchun 130021Jilin ProvinceChina The Key Laboratory of PathobiologyMinistry of EducationCollege of Basic Medical SciencesJilin UniversityChangchun 130021Jilin ProvinceChina
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第36期
页 面：6004-6024页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Pancreatic cancer Epigenetics Histone modification Methylation Demethylation Clinical application
摘 要：Pancreatic cancer(PC)is an aggressive human *** methods for the diagnosis and treatment of PC have not been found at the genetic level,thus making epigenetics a promising research path in studies of *** methylation is one of the most complicated types of epigenetic modifications and has proved crucial in the development of *** methylation is a reversible process regulated by readers,writers,and *** writers and erasers can be recognized as potential biomarkers and candidate therapeutic targets in PC because of their unusual expression in PC cells compared with normal pancreatic *** on the impact that writers have on the development of PC,some inhibitors of writers have been ***,few inhibitors of erasers have been developed and put to clinical ***,there is not enough research on the reader ***,the study of erasers and readers is still a promising *** review focuses on the regulatory mechanism of histone methylation,and the diagnosis and chemotherapy of PC based on *** future of epigenetic modification in PC research is also discussed.
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