Association between rs1761667 CD36 polymorphism and risk of stroke in Korean patients with type 2 diabetes

作     者：Dong-Hwa Lee Gun Woo Won Yong Hee Lee Jong Sung Shin Eu Jeong Ku Tae Keun Oh Hyun Jeong Jeon Lee Dong-Hwa;Won Gun Woo;Lee Yong Hee;Shin Jong Sung;Ku Eu Jeong;Oh Tae Keun;Jeon Hyun Jeong

作者机构：Department of Internal MedicineChungbuk National University College of Medicine and Chungbuk National University HospitalCheongjuRepublic of Korea Department of BiochemistryChungbuk National University College of MedicineCheongjuRepublic of Korea Hanmi Internal Medicine ClinicCheongjuRepublic of Korea 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第19期

页      面：2385-2387页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the Chungbuk National University College of Medicine 

主　　题：CD36 T2DM patients 

摘      要：To the Editor:As the prevalence of stroke in the general population is two to three times less than among patients with type 2 diabetes mellitus(T2DM),among whom stroke accounts for 11.0%of all deaths,stroke is clearly a major macrovascular complication that increases the mortality and morbidity of patients with T2DM.[1]The pathophysiology of stroke consists of complicated processes involving oxidative stress,endothelial dysfunction,and pro-inflammatory ***36 is a B scavenger receptor that is involved in inflammation,innate immunity,and lipid metabolism and has been implicated in the pathophysiology of atherosclerosis.[2]However,there is no study evaluating the effect of CD36 polymorphism in patients with T2DM according to disease ***,the present study evaluates the association between the rs1761667 CD36 single nucleotide polymorphism(SNP)and stroke in Korean patients with T2DM according to disease duration.