Evaluation of the prognostic ability of serum uric acid for elderly acute coronary syndrome patients with diabetes mellitus:a prospective cohort study

作     者：Yang JIAO Jihang WANG Xia YANG Mingzhi SHEN Hao XUE Jun GUO Wei DONG Yundai CHEN Qing XI Zhenhong FU Yang JIAO;Jihang WANG;Xia YANG;Mingzhi SHEN;Hao XUE;Jun GUO;Wei DONG;Yundai CHEN;Qing XI;Zhenhong FU

作者机构：Senior Department of Cardiologythe Sixth Medical Center of PLA General Hospital&Chinese PLA Medical SchoolBeijing 100853China Department of CardiologyHainan HospitalChinese PLA General HospitalSanya 572000China The First Medical CenterChinese PLA General HospitalBeijing 100853China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2021年第22卷第10期

页      面：856-865页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Uric acid Elderly patient Acute coronary syndrome Diabetes mellitus Prognosis 

摘      要：Objective:This study evaluated the prognostic power of serum uric acid(UA)in predicting adverse events in elderly acute coronary syndrome(ACS)patients with diabetes mellitus(DM).Methods:The analysis involved 718 ACS patients80 years old whose general clinical data and baseline blood biochemical indicators were collected prospectively from January 2006 to December *** patients were classified into two groups based on DM status,and then followed up after *** Kaplan-Meier method was used for major adverse cardiac event(MACE)rates and all-cause *** Cox regression was performed to analyze the relationship between UA level and long-term clinical *** operating characteristic(ROC)curves were analyzed to predict the cutoff value of UA in elderly ACS patients with *** were 242 and 476 patients in the DM and non-DM(NDM)groups,respectively,and the follow-up time after discharge was 40‒120 months(median,63 months;interquartile range,51‒74 months).Results:The all-cause mortality,cardiac mortality,and MACE rates in both DM and NDM patients were higher than those in the control group(P=0.001).All-cause mortalities,cardiac mortalities,and MACE rates in DM patients with moderate and high UA levels were significantly higher than those in the NDM group(P=0.001).Long-term survival rates decreased significantly with increased UA levels in the ACS groups(P=0.001).UA(odds ratio(OR)=2.106,95%confidence interval(CI)=1.244‒3.568,P=0.006)was found to be an independent risk factor for all-cause mortality and MACE in elderly ACS patients with *** cutoff value of UA was 353.6μmol/L(sensitivity,67.4%;specificity,65.7%).Conclusions:Serum UA level is a strong independent predictor of long-term all-cause death and MACE in elderly ACS patients with DM.