Mesenchymal stem cells and COVID-19: What they do and what they can do
作者机构：Department of Physiology and PathophysiologyUniversity of ManitobaWinnipeg R2H2A6Canada Department of Physiology and PathophysiologyBasic Medical SciencesYarmouk UniversityIRBID 21163Jordan Department of Anatomy and HistologyBasic Medical SciencesYarmouk UniversityIRBID 21163Jordan Department of Physiology and PharmacologyBasic Medical SciencesYarmouk UniversityIRBID 21163Jordan Department of Biochemistry and GeneticsBasic Medical SciencesYarmouk UniversityIRBID 21163Jordan Department of PathologyBasic Medical SciencesYarmouk UniversityIRBID 21163Jordan Department of Pharmacology and TherapeuticsUniversity of ManitobaWinnipeg R2H2A6Canada Department of PharmacologySaveetha Dental College and Hospitals to be UniversityChennai 600077India
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第9期
页 面：1318-1337页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：SARS-CoV-2 COVID-19 Mesenchymal stem cells Inflammation Acute respiratory distress syndrome Pulmonary fibrosis Pneumonia Renal injury Cardiovascular diseases Regeneration Anti-inflammatory
摘 要：The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) orcoronavirus disease 2019 (COVID-19) pandemic has exhausted the health systemsin many countries with thousands cases diagnosed daily. The currently usedtreatment guideline is to manage the common symptoms like fever and cough,but doesn’t target the virus itself or halts serious complications arising from thisviral infection. Currently, SARS-CoV-2 exhibits many genetic modulations whichhave been associated with the appearance of highly contagious strains. Thenumber of critical cases of COVID-19 increases markedly, and many of theinfected people die as a result of respiratory failure and multiple organ dysfunction. The regenerative potential of mesenchymal stem cells (MSCs) has beenextensively studied and confirmed. The impressive immunomodulation and antiinflammatoryactivity of MSCs have been recognized as a golden opportunity forthe treatment of COVID-19 and its associated complications. Moreover, MSCsregenerative and repairing abilities have been corroborated by many studies withpositive outcomes and high recovery rates. Based on that, MSCs infusion could bean effective mechanism in managing and stemming the serious complications andmultiple organ failure associated with COVID-19. In the present review, wediscuss the commonly reported complications of COVID-19 viral infection and theestablished and anticipated role of MSCs in managing these complications.
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