Coronary vasospasm:A narrative review

作     者：Jacob Jewulski Sumesh Khanal Khagendra Dahal 

作者机构：Foundational Medical StudiesOakland University William Beaumont School of MedicineRochesterMI 48309United States Department of Internal MedicineWilliam Beaumont HospitalRoyal OakMI 48073United States Department of CardiologyCHI HealthCreighton University School of MedicineOmahaNE 68118United States 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2021年第13卷第9期

页      面：456-463页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Coronary artery vasospasm Vasospastic angina Prinzmetal angina Variant angina Coronary artery disease 

摘      要：Coronary artery vasospasm(CAVS)plays an important role in acute chest pain syndrome caused by transient and partial or complete occlusion of the coronary *** of the disease remains incompletely understood,with autonomic and endothelial dysfunction thought to play an important *** to the dynamic nature of the disease,its exact prevalence is not entirely clear but is found to be more prevalent in East Asian and female *** smoking remains a prominent risk factor,although CAVS does not follow traditional coronary artery disease risk *** triggers continue to be identified,with recent findings identifying chemotherapeutics,allergens,and inflammatory mediators as playing some role in the exacerbation of *** testing with direct visualization is currently the gold-standard for diagnosis,but non-invasive tests,including the use of biomarkers,are being increasingly studied to aid in the *** of the CAVS is an area of active *** from risk factor modification,calcium channel blockers are currently the first line treatment,with nitrates playing an important adjunct ***-risk patients with life-threatening complications should be considered for implantable cardioverter defibrillator(ICD),although timing criteria for escalated therapy require further *** role of pharmaceuticals targeting oxidative stress remains incompletely understood.