A review of mechanisms of resistance to immune checkpoint inhibitors and potential strategies for therapy

作     者：Yu Fujiwara Arjun Mittra Abdul Rafeh Naqash Naoko Takebe 

作者机构：Developmental Therapeutics ClinicDivision of Cancer Treatment and DiagnosisNational Cancer InstituteBethesdaMD 20892USA. Department of Medical OncologyThe Cancer Institute Hospital of Japanese Foundation for Cancer ResearchTokyo 1358550Japan Department of Medical OncologyMusashino Red Cross HospitalTokyo 1800023Japan 

出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)

年 卷 期：2020年第3卷第3期

页      面：252-275页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Immunotherapy resistance tumor microenvironment PD-1 PD-L1 CTLA-4 

摘      要：Immune checkpoint inhibitors(ICIs)have revolutionized the treatment of cancer over the last decade,bringing about a paradigm shift in systemic cancer therapy away from traditional cytotoxic and targeted *** some patients have dramatic treatment responses,it is sobering to note that most tumors are either resistant at the outset,or develop resistance after initial response.A major area of translational and clinical research is in identifying therapeutic strategies to overcome resistance to *** have performed an in-depth review of the different mechanisms of resistance and potential avenues to overcome resistance through rationally designed combination treatment with ICIs.