Reproductive outcomes of intracytoplasmic sperm injection using testicular sperm and ejaculated sperm in patients with AZFc microdeletions:a systematic review and meta-analysis
作者机构：Department of UrologyThe First Affiliated HospitalJinan UniversityGuangzhou 510630China NHC Key Laboratory of Male Reproduction and GeneticsFamily Planning Research Institute of Guangdong ProvinceGuangzhou 510600China Digestive Diseases CenterThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Department of AndrologyGuangzhou First People's HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2021年第23卷第5期
页 面：495-500页
核心收录：
基 金：the Project of Medical Science and Technology Research Foundation of Guangdong Province(No.A2019336) Guangzhou Science and Technology Plan Project(No.201707010394).
主 题：assisted reproductive technology azoospermia factor c microdeletions ejaculated sperm live birth rate testicular sperm
摘 要：Studies have explored the assisted reproductive technology(ART)outcomes of Y-chromosome azoospermia factor c(AZFc)microdeletions,but the effect of sperm source on intracytoplasmic sperm injection(ICSI)remains unknown.To determine the ART results of ICSI using testicular sperm and ejaculated sperm from males with AZFc microdeletions,we searched Embase,Web of Science,and PubMed to conduct a systematic review and meta-analysis.The first meta-analysis results for 106 cycles in five studies showed no significant differences in the live birth rate between the testicular sperm group and the ejaculated sperm group(risk ratio:0.97,95%confidence interval[CI]:0.73-1.28,P=0.82).The second meta-analysis of 106 cycles in five studies showed no difference in the abortion rate between the testicular sperm group and ejaculated sperm group(risk ratio:1.06,95%Cl:0.54-2.06,P=0.87).The third meta-analysis of 386 cycles in seven studies showed no significant difference in clinical pregnancy rates between the testicular sperm group and the ejaculated sperm group(risk ratio:1.24,95%Cl:0.66-2.34,P=0.50).Inevitable heterogeneity weakened our results.However,our results indicated that testicular sperm and ejaculated sperm yield similar ART outcomes,representing a meaningful result for clinical treatment.More properly designed studies are needed to further confirm our conclusions.
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