New possibilities in treatment of chronic urinary tract infections-vaccines, autovaccines and beta glucans

作     者：Josef Richter Vaclav Vetvicka Karola Haasova Romana Mikesova Ivana Stiborova Vlastimil Kral Josef Richter;Vaclav Vetvicka;Karola Haasova;Romana Mikesova;Ivana Stiborova;Vlastimil Kral

作者机构：Zdravotníústav se sídlem vÚstínad LabemÚstínad LabemCzech Republic Department of PathologyUniversity of LouisvilleLouisvilleKYUSA 

出 版 物：《临床与病理杂志》 (Journal of Clinical and Pathological Research)

年 卷 期：2021年第41卷第9期

页      面：1977-1981页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

主　　题：Urinary tract infection autovaccine Beta glucan 

摘      要：Background:Repeated infections of urinary tract manifest an increasing trend and became the most common infection in developed *** addition,currently common increase in resistant microbes including uropathogens underlines the need for new ways of urinary tract infection(UTI)*** of the possibilities is ***,commercially available bacterial vaccines are not always reliable,leading to the proposition of using autovaccines prepared from uropathogens of individual *** is a well-known fact that UTIs are often accompanied by depressed ***:To respond to both problems,we tried to use yeast-derived,insoluble beta glucans for restoration of depressed immune system and acceleration of the effects of *** all patients we repeatedly tested bacterial load in *** addition,from the same samples we measured the levels of inflammatory proteins,albumin,orosomukoid,IgA,C-reactive *** evaluation of inflammatory response and cellular immunity in blood was performed,***:Immediately after application of the first dose we observed significant improvements of clinical conditions which were persistent throughout the entire ***:Beta glucan is optimal addition to autovaccines,as it is natural,active,safe and *** propose that the possibility to use beta glucans in application of autovaccines is the first step in preparation of qualitative new type of autovaccines against UTI.