Enzymatic Synthesis of a Diastereomer of Neoabyssomicin Derivative Using the Diels-Alderase AbyU
作者机构：CAS Key Laboratory of Tropical Marine Bio-Resources and EcologyGuangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of Sciences164 West Xingang RoadGuangzhouGuangdong510301 China College of OceanologyUniversity of Chinese Academy of Sciences19 Yuquan RoadBeijing100049 China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)No.1119Haibin Rd.Nansha DistrictGuangzhouGuangdong510301 China State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing100191 China Key Laboratory of Plant Resources Conservation and Sustainable UtilizationSouth China Botanical GardenChinese Academy of SciencesGuangzhouGuangdong510650 China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2021年第39卷第7期
页 面：1871-1877页
核心收录：
学科分类：07[理学] 070303[理学-有机化学] 0703[理学-化学]
基 金：This work was supported by the China NSF(Nos.31670087 and U1706206) the Natural Key Research and Development Program of China(No.2019YFC0312500) the Key Special Project for Introduced Talents Team of Southern Marine Science and Engi-neering Guangdong Laboratory(Guangzhou,No.GML2019ZD0406) the Guangdong NSF(No.2016A030312014) the Guangdong Local Innovation Team Program(No.2019BT02Y262) the Pearl River S&T Nova Program of Guangzhou No.201806010109) the CAS(No.XDA13020302-2) the Guangdong Provincial-Level Special Funds for Promoting High-quality Economic Development(No.2020032).
主 题：Biosynthesis Bioorganic chemistry Enzyme catalysis Neoabyssomicin Diels-Alderase
摘 要：Main observation and conclusion The enzyme AbyU catalyses a Diels-Alder(DA)reaction during abyssomicin C biosynthesis.In this study,AbyU is shown to convert the native substrate of another Diels-Alderase(DAase),AbmU,to a new abyssomicin derivative,abyssomicin 7.
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