DNA direct reversal repair and alkylating agent drug resistance

作     者：Roberto Gutierrez Timothy R.O’Connor 

作者机构：Department of Cancer BiologyBeckman Research InstituteCity of HopeDuarteCA 91010USA Irell&Manella Graduate School of Biological SciencesCity of HopeDuarteCA 91010USA Department of Cancer BiologyBeckman Research InstituteCity of HopeDuarteCA 91010USA. 

出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)

年 卷 期：2021年第4卷第2期

页      面：414-423页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：California Tobacco-Related Disease Research Program Grant:Combined genotoxic effects of alternative tobacco products and alcohol use(No.28IR-0050 TRO) 

主　　题：Direct reversal repair O6-methylguanine-DNA methyltransferase AlkB homologs resistance to alkylating agents 

摘      要：DNA direct reversal repair(DRR)is unique in that no DNA synthesis is required to correct the error and therefore repair via such mechanisms are *** humans,DRR is carried out by two different pathways:the O6-methylguanine-DNA methyltransferase(MGMT)and the alkylated DNA repair protein B(AlkB)*** use of alkylating agents is the standard of care for many ***,the use of those drugs is usually halted when resistance *** review will examine repair of alkylating agent damage mediated by DRR,resistance mechanisms and potential ways to overcome such resistance.