Stress and drug resistance in cancer
作者机构：School of Pharmacy and Biomolecular SciencesUniversity of BrightonMoulsecoombBrightonBN24GJUK.
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2019年第2卷第3期
页 面：773-786页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cancer catecholamines dexamethasone drug resistance glucocorticoids
摘 要：Patients diagnosed with cancer often undergo considerable psychological distress,and the induction of the psychological stress response has been linked with a poor response to *** psychological stress response is mediated by fluctuations of the hormones glucocorticoids(GCs)and *** to their respective receptors,GCs and the catecholamines adrenaline/noradrenaline are responsible for signalling a wide range of processes involved in cell survival,cell cycle and immune *** GCs are also often prescribed as co-medication alongside chemotherapy,and increasing evidence suggests that GCs may induce chemoresistance in multiple cancer *** this review,we bring together evidence linking psychological stress hormone signalling with resistance to chemo-and immune therapies,as well as mechanistic evidence regarding the effects of exogenous stress hormones on the efficacy of chemotherapies.
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