Engineering immune-responsive biomaterials for skin regeneration
作者机构：College of Chemistry and Environmental ScienceHebei UniversityBaodingHebei ProvinceChina Affiliated Hospital of Hebei UniversityCollege of Chemistry and Environmental ScienceHebei UniversityBaodingHebei ProvinceChina
出 版 物：《Biomaterials Translational》 (生物材料转化电子杂志（英文）)
年 卷 期：2021年第2卷第1期
页 面：61-71页
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(No.31700845) Hebei DHRSS Research Fund,China(No.E2019100005) the High-level Talents Research Start-up Project of Hebei University,China(Nos.521000981393,521000981336)
主 题：biomaterials immune cells immunoresponse skin regeneration
摘 要：The progress of biomaterials and tissue engineering has led to significant advances in wound healing,but the clinical therapy to regenerate perfect skin remains a great *** implantation of biomaterial scaffolds to heal wounds inevitably leads to a host immune *** recent studies revealed that the immune system plays a significant role in both the healing process and the *** or immuno-engineering has thus become a promising approach to develop pro-regenerative scaffolds for perfect skin *** this paper,we will review recent advancements in immunomodulating biomaterials in the field of skin repair and regeneration,and discuss strategies to modulate the immune response by tailoring the chemical,physical and biological properties of the *** the important role of immune responses and manipulating the inherent properties of biomaterials to regulate the immune reaction are approaches to overcome the current bottleneck of skin repair and regeneration.
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