Dysbiosis of Gut Microbiota Contributes to the Development of Diabetes Mellitus

作     者：Jian Lu Kun Ling Ma Xiong Zhong Ruan 

作者机构：Institute of NephrologyZhongda HospitalSchool of MedicineSoutheast UniversityNanjing210009China Centre for Lipid Research&Key Laboratory of Molecular Biology for Infectious Diseases(Ministry of Education)Institute for Viral HepatitisDepartment of Infectious DiseasesThe Second Affiliated HospitalChongqing Medical University400016 ChongqingChina The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases(CCID)Zhejiang University310058 HangzhouChina John Moorhead Research LaboratoryCentre for NephrologyUniversity College London Medical SchoolRoyal Free CampusUniversity College LondonLondon NW32PFUnited Kingdom 

出 版 物：《Infectious Microbes & Diseases》 (感染微生物与疾病（英文）)

年 卷 期：2019年第1卷第2期

页      面：43-48页

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：This work was supported by the Jiangsu Province Social Development Project(BE2018744) the Project for Jiangsu Provincial Medical Talent(ZDRCA2016077) the Fundamental Research Funds for the Central Universities(KYCX18-0182) Joint Project of Southeast University and Pharmaceutical University of China(2242019K3DZ03) Shenzhen Science&Technology Program(JCYJ20151029154245758,CKFW2016082915204709) 

主　　题：diabetes mellitus gut microbiota metabolites 

摘      要：Accumulating evidence has revealed that the composition of gut microbiota in patients with diabetes mellitus(DM)varies compared to those with healthy *** abnormal production and releases of metabolites derived from microbiota into the blood circulation contribute to the development of DM through the activation of multiple metabolic pathways,including trimethylamine Noxide,short-chain fatty acids,lipopolysaccharide,aromatic amino acids,and their related ***,the modulation of gut microbiota through dietary intervention,probiotics,broad-spectrum antibiotics,and fecal microbiota transplantation could be a potential therapeutic approach for *** review mainly summarized the complicated interactions of gut microbiota through its metabolites with DM.