Longitudinal monitoring and prediction of long-term outcome of scar stiffness on pediatric patients

作     者：Bettina Müller Edoardo Mazza Clemens Schiestl Julia Elrod 

作者机构：Institute for Mechanical SystemsDepartment of Mechanical and Process EngineeringETH ZurichLeonhardstrasse 218092 ZurichSwitzerland EmpaSwiss Federal Laboratories for Materials Science and TechnologyUeberlandstrasse 1298600 DübendorfSwitzerland Burn CenterDivision of Plastic and Reconstructive SurgeryUniversity Children’s Hospital ZurichSteinwiesstrasse 758032 ZürichSwitzerland Children’s Research Center(CRC)University Children’s Hospital ZurichSteinwiesstrasse 758032 ZürichSwitzerland 

出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)

年 卷 期：2021年第9卷第1期

页      面：196-206页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the Helmut Horten Foundation 

主　　题：Pediatric burns Scar maturation POSAS Cutometer Nimble 

摘      要：Background:Hypertrophic scarring after burn injury is one of the greatest unmet challenges in patients with burn injuries.A better understanding of the characteristics of scar maturation and early prediction of the long-term outcome of scarring are prerequisites for improving targeted therapies and pivotal for patient ***:Repeated measurements of scar stiffness in 11 pediatric patients were performed over the course of 1 year using 2 suction devices,the Cutometer and the *** addition,the observer pliability score of the Patient and Observer Scar Assessment Scale was *** longitudinal study allowed quantification of the ability of each of the measured parameters to reflect scar maturation,as indicated by change in skin pliability/stiffness,over time(using linear regression);the ability to distinguish individual patients(intraclass correlation coefficient(ICC));the correlation of the devices(Spearman correlation coefficient);and the ability to predict longterm scar maturation based on early scar assessment(using receiver operating characteristic).Results:All the tools used showed significant longitudinal decrease of scar stiffness from 3 months until 12 months after the *** Nimble(ICC_(patient)^(Nimble)=0.99)and the Cutometer(ICC_(patient)^(Cuto)=0.97)demonstrated an excellent ability to distinguish between individual *** Nimble seemed to be able to predict the 12-month pliability of scars based on early(3-month)measurements(area under the curve(AUC)_(12m)^(POSAS)=0.67;AUC_(12m)^(C)=0.46;AUC_(12m)^(N)=0.79).Conclusions:The results of this preliminary study suggest that all 3 tools provide suitable means to quantify alterations in scar stiffness over *** evidence suggests the Nimble is most favorable for predicting changes in stiffness associated with long-term scar *** studies with a larger sample size are required to validate tissue suction as a clinical tool for analysis of changes of scar stiffne