Potential utility of liquid biopsies in the management of patients with biliary tract cancers:A review
作者机构：Department of Medical OncologyThe Christie NHS Foundation TrustManchester M204BXUnited Kingdom Division of Cancer SciencesSchool of Medical SciencesFaculty of BiologyMedicine and HealthUniversity of ManchesterManchester M139PLUnited Kingdom
出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)
年 卷 期：2021年第13卷第9期
页 面：1073-1085页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Bureau for Imaging Equipment Limited Celgene and Nucana NuCana Wren Laboratories Pfizer Bayer Servier Ipsen
主 题：Biliary tract cancer Liquid biopsy Circulating tumour DNA Cell free DNA Circulating tumour cells Biomarkers
摘 要：Biliary tract cancer,comprising gallbladder cancer,cholangiocarcinoma and ampullary cancer,represents a more uncommon entity outside high-endemic areas,though global incidence is *** majority of patients present at a late stage,and 5-year survival remains *** stage disease is incurable,and though palliative chemotherapy has been shown to improve survival,further diagnostic and therapeutic options are required in order to improve patient *** certain subtypes of biliary tract cancer are relatively rich in targetable mutations,attaining tumour tissue for histological diagnosis and treatment monitoring is challenging due to locoregional anatomical constraints and patient *** biopsies offer a safe and convenient alternative to invasive procedures and have great potential as diagnostic,predictive and prognostic *** this review,the current standard of care for patients with biliary tract cancer,future treatment horizons and the possible utility of liquid biopsies within a variety of contexts will be *** tumour DNA,circulating microRNA and circulating tumour cells are discussed with an overview of their potential applications in management of biliary tract cancer.A summary is also provided of currently recruiting clinical trials incorporating liquid biopsies within biliary tract cancer research.
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