Focused evaluation of the roles of macrophages in chimeric antigen receptor (CAR) T cell therapy associated cytokine release syndrome

作     者：Hanfei Guo Lei Qian Jiuwei Cui Hanfei Guo;Lei Qian;Jiuwei Cui

作者机构：Cancer Centerthe First Hospital of Jilin UniversityChangchun 130021China 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2022年第19卷第3期

页      面：333-342页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants from the National Key Research and Development Program of China(Grant No.2020YFA0707704) the National Key Research and Development Program of China(Grant No.2016YFC1303800) the Jilin Scientific and Technological Development Program(CN)(Grant No.20190303146SF) the National Natural Science Foundation of China(Grant No.81874052) 

主　　题：Chimeric antigen receptor CAR T cells cytokine release syndrome macrophage 

摘      要：Cytokine release syndrome(CRS)is a major obstacle to the widespread clinical application of chimeric antigen receptor(CAR)T cell *** can also be induced by infections(such as SARS-CoV-2),drugs(such as therapeutic antibodies),and some autoimmune ***-derived macrophages play key roles in the pathogenesis of CRS,and participate in the production and release of the core CRS cytokines,including interleukin(IL)-1,IL-6,and interferon-γ.In this review,we summarize the roles of macrophages in CRS and discuss new developments in macrophage activation and the related mechanisms of cytokine regulation in CRS.