Fluid and Osmotic Pressure Balance and Volume Stabilization in Cells Dedicated to Professor Karl Stark Pister for his 95th birthday
作者机构：Department of Mechanical EngineeringStanford UniversityStanford94305CAUSA
出 版 物：《Computer Modeling in Engineering & Sciences》 (工程与科学中的计算机建模（英文）)
年 卷 期：2021年第129卷第12期
页 面：1329-1350页
核心收录：
学科分类：07[理学] 0701[理学-数学] 070101[理学-基础数学]
主 题：Pump-leak mechanism cell volume regulation active ion transport ion pump membrane transport cell mechanics modified Kedem-Katchalsky equations nonequilibrium thermodynamics phenomenological equations
摘 要：A fundamental problem for cells with their fragile membranes is the control of their *** primordial solution to this problem is the active transport of ions across the cell membrane to modulate the intracellular osmotic *** this work,a theoretical model of the cellular pump-leak mechanism is proposed within the general framework of linear nonequilibrium *** model is expressed with phenomenological equations that describe passive and active ionic transport across cell membranes,supplemented by an equation for the membrane potential that accounts for the electrogenicity of the ionic *** active ionic transport,the model predicts that the intracellular fluid pressure will be balanced by the osmotic pressure and a new pressure component that arises from the active ionic fluxes.A model for the pump-leak mechanism in an idealized human cell is introduced to demonstrate the applicability of the proposed theory.
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