在药物性落叶型天疱疮中停用D-青霉胺可使抗桥粒芯糖蛋白1IgGELISA得分降低
Deline of anti-desmoglein I IgG ELISA scores by withdrawal of D-penicllamine in drug-induced peluphigus foliaceus作者机构：Keio University School of Med icine Department of Dermatology 35 Shinanomachi Shinjuku-ku Tokyo Japan
出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2005年第1卷第5期
页 面：58-58页
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
主 题：落叶型天疱疮 IgGELISA 青霉胺 桥粒芯糖蛋白 系统性硬化症
摘 要：A case of pemphigus foliaceus arising during the administration of D-penicill amine was reported. A 72-year-old woman with systemic sclerosis developed flac cid vesicles and crusted erythema of the skin after administration of D-penicil lamine for 1-year. She was positive for anti-desmoglein 1 IgG by ELISA. The wi thdrawal of D-penicillamine resulted in improvement of theskinlesionsand ELISAs coresforanti-demoglein1antibodies revealed a surprisingly rapid decline. This c ase is a classical incidence of drug-induced pemphigus foliaceus, in which D-p enicillamine was constantly required not only to induce, but also to maintain th e production of the autoantibodies.
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