Hypothalamic-Pituitary-End-Organ Axes:Hormone Function in Female Patients with Major Depressive Disorder
作者机构：Division of Mood DisordersShanghai Hongkou Mental Health CenterShanghai200083China Clinical Research CenterShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai200030China Shanghai Medical CollegeFudan UniversityShanghai200032China Shanghai Yangpu Mental Health CenterShanghai200093China CAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai200031China Shanghai Key Laboratory of Psychotic DisordersShanghai201108China
出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)
年 卷 期：2021年第37卷第8期
页 面：1176-1187页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：the National Key Research and Development Program of China(2016YFC1307100,2016YFC1307105) the National Natural Science Foundation of China(81771465,81930033) the National Key Technologies R&D Program of China(2012BAI01B04) Shanghai Key Project of Science and Technology(2018SHZDZX05) the Sanming Project of Medicine in Shenzheng(SZSM201612006) Shanghai Key Medicine Specialties Program(ZK2019A06) Shanghai Clinical Research Center for Mental Health(SCRC-MH,19MC1911100) the Special Project for Clinical Research in Health Industry of Shanghai Municipal Health Commission(20204Y0025) the Innovative Research Team of High-level Local Universities in Shanghai,and the National Health System“Good Doctor”Construction Project of Yangpu District of Shanghai Municipality(2020-2023).
主 题：Major depressive disorder Neurosecretory systems Sex steroid hormones
摘 要：Classic hypothalamic-pituitary-end-organ feedback loops–the hypothalamic-pituitary-adrenal axis(HPAA),hypothalamic-pituitary-thyroidal axis(HPTA),and hypothalamic-pituitary-gonadal axis(HPGA)–are associated with the neuroendocrine and immune systems in major depressive disorder(MDD).Female patients with MDD present with evident neuroendocrine and immunological changes.Glucocorticoid,thyroid hormone,and reproductive steroid levels fluctuate with menstrual cycles,which might lead to glucocorticoid receptor resistance,impairment of triiodothyronine conversion,and sex hormone secretion disorders.In this review,we summarize the independent and interactive functions of these three axes in female MDD patients.The similar molecular structure of steroids implies an interrelationship between the hypothalamic-pituitary-end-organ axes and the competitive inhibitory effects at the receptor level,especially when considering the HPAA and HPGA.
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