How the “seed” prepares the “soil”: the bone/bone marrow pre-metastatic niche
作者机构：Department of Biotechnological and Applied Clinical SciencesUniversity of L’AquilaL’Aquila 67100Italy.
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2021年第7卷第1期
页 面：478-496页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by“Associazione Italiana per la Ricerca sul Cancro”(AIRC #IG2015Id.16826)to Rucci N and by the AIRC-FIRC fellowships to Maurizi A and Ponzetti M(#22356 and#24019) respectively
主 题：Bone metastasis pre-metastatic niche bone microenvironment extracellular vesicles
摘 要：Cancer is one of the leading causes of death in women and men *** fatal outcome usually occurs after metastatic dissemination,and bone is by far the most common site of metastasis for breast and prostate cancer,the highest incidence neoplasia in women and men,***,while this is clear,the mechanisms through which the metastatic preference is established is *** emerging concept in this regard is the pre-metastatic niche(PMN)establishment,i.e.,the process through which tumors can influence the bone microenvironment from the primary site and make it permissive for their engraftment,before they migrate to the blood flow and *** this review,we discuss key microenvironmental players in the bone/bone marrow PMN,including osteoblasts,osteoclasts,and bone marrow *** also describe the known PMN-educating factors,as well as the role of extracellular vesicles as emerging players in the bone/bone marrow *** overview of current therapeutic developments aimed at targeting the bone PMN is also provided.
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