Calculation of the intake retention fraction and dose coefficients in ^99mTc-labelled compound for internal exposure for medical workers

作     者：Tae-Eun Kwon Siwan Noh Sol Jeong Jai-Ki Lee 

作者机构：Hanyang University 222 Wangsimni-ro Seongdong-gu Seoul Republic of Korea 

出 版 物：《Nuclear Science and Techniques》 (核技术（英文）)

年 卷 期：2014年第25卷第A1期

页      面：15-19页

核心收录：

学科分类：083002[工学-环境工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 08[工学] 0807[工学-动力工程及工程热物理] 09[农学] 0903[农学-农业资源与环境] 0827[工学-核科学与技术] 0703[理学-化学] 0702[理学-物理学] 0801[工学-力学（可授工学、理学学位）] 0713[理学-生态学] 

基　　金：National Emergency Management Agency of Korea Ministry of Environment of Korea 

主　　题：标记化合物 医务工作者 辐射剂量 计算 曝光 部分和 呼吸道模型 生理信息 

摘      要：For recent decades, a considerable amount of 99mTc has been stimulated for diagnosis radiopharmaceuticals because of its physical advantages. The increase in the use of 99mTc makes naturally more chances of internal exposure for not only patients but also medical workers. The patient internal exposure by an intravenous injection has been assessed relatively well with the reports of International Commission on Radiological Protection (ICRP) or Medical Internal Radiation Dose(MIRD). However, there are few studies which can support its accurate assessment for medical worker who treats 99mTc. In spite of the absence of information, the physiological information of each 99mTc-labelled compound for patient, provided by ICRP, can be used optionally for worker exposure because the behaviors after uptake to blood are similar for patient and worker. Using the data, in this study, the data for bioassay were given as the intake whole-body retention and urinary excretion function. We selected the two most frequently used 99mTc-labelled compounds based on statistical data; 99mTc-phosphonate, pertechnetate. The data of the Human Alimentary Tract Model (HATM, publication 100) and the revised Human Respiratory Tract Model (revised HRTM, OIR) were used for compartment models which depict the physiological behavior in body after intake. In case of 99mTc-phosphonate, we adopted the systemic model for patient intake described in ICRP publication 53 based on the assumption that the behaviors after uptake to blood are similar for patient and worker. On the other hand, recent updated systemic model in OIR report could be directly adopted for pertechnetate. We used Birchall s algorithm for calculation and developed the module which could calculate the retention amounts in each compartment at given time by MATLAB. In addition, we fitted the functions as sum of exponential terms using ORIGIN and the fitting coefficients were provided. We also could calculate the committed dose coefficients fo