Could the burden of pancreatic cancer originate in childhood?

作     者：Smaranda Diaconescu Georgiana Emmanuela Gîlcă-Blanariu Silvia Poamaneagra Otilia Marginean Gabriela Paduraru Gabriela Stefanescu 

作者机构：Department of Pediatrics“Grigore T.Popa”University of Medicine and PharmacyIasi 700115Romania Department of Pediatric GastroenterologySt Mary Emergency Children's HospitalIasi 700309Romania Department of Gastroenterology and Hepatology"Grigore T.Popa"University of Medicine and PharmacyIasi 700115Romania Department of Gastroenterology and Hepatology“St.Spiridon”Emergency HospitalIasi 700111Romania Doctoral SchoolGeorge Emil Palade University of MedicinePharmacyScience and TechnologyTargu Mures 540142Romania Department of PediatricsResearch Center of Disturbance of Growth and Development on Children-BeliveUniversity of Medicine and Pharmacy“Victor Babes”TimisoaraTimisoara 300041Romania First Clinic of Pediatrics"Louis Turcanu"Emergency Childen's HospitalTimisoara 300011Romania 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第32期

页      面：5322-5340页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Pancreatic cancer Pancreatic metastasis Childhood Adult Screening Transition 

摘      要：The presence of pancreatic cancer during childhood is extremely rare,and physicians may be tempted to overlook this diagnosis based on age ***,there are primary malignant pancreatic tumors encountered in pediatric patients,such as pancreatoblastoma,and tumors considered benign in general but may present a malignant potential,such as the solid pseudo-papillary tumor,insulinoma,gastrinoma,and vasoactive intestinal peptide secreting *** early diagnosis and management are of paramount importance since the survival rates tend to differ for various types of these *** pediatric cancers may present pancreatic metastases,such as renal cell carcinoma,which may evolve with pancreatic metastatic disease even after two or more *** childhood diseases may create a predisposition for the development of pancreatic cancer during adulthood;hence,there is a need for extensive screening strategies and complex programs to facilitate the transition from pediatric to adult ***,genetic studies highlight the fact the specific gene mutations and family aggregations may be correlated with a special predisposition towards pancreatic *** review aims to report the main pancreatic cancers diagnosed during childhood,the most important childhood diseases predisposing to the development of pancreatic malignancies,and the gene mutations associates with pancreatic malignant tumors.