Research progress on naturally-occurring and semi-synthetic ocotillol-type ginsenosides in the genus Panax L.(Araliaceae)

作     者：NIU Xue-Ni LUO Wen LV Chong-Ning LU Jin-Cai NIU Xue-Ni;LUO Wen;LV Chong-Ning;LU Jin-Cai

作者机构：Department of Traditional Chinese MedicineShenyang Pharmaceutical UniversityShenyang 110016China 

出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)

年 卷 期：2021年第19卷第9期

页      面：648-655页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Key R&D Program of China(No.2017YFC1702302) 

主　　题：Ocotillol-type ginsenosides Panax species Panax quinquefolius Structure-activity relationship 

摘      要：Ocotillol(OT)-type ginsenosides,one subtype of ginsenosides,consist of a dammarane skeleton and a tetrahydrofuran *** naturally-occurring OT-type ginsenosides exist in Panax species,particularly in Panax quinquefolius,which may be attributed to the warm and humid climate of its native *** now,merely 28 types of naturally-occurring OT-type ginsenosides have been *** contrast,semi-synthesized OT-type ginsenosides are attracted considerable *** ginsenosides can be obtained through oxidation and cyclization of side chains of dammarane-type ginsenosides,and other methods,which may change their physical and chemical properties and further improve their *** is also notable that the pharmacological activities of ginsenosides are closely related to the stereoisomers caused by the configuration at ***-synthesis of OT-type ginsenosides can facilitate our understanding of the biosynthesis,transformation and metabolism of OT-type ginsenosides in the *** review will systematically summarize the research progress on naturally-occurring and semi-synthetic OT-type ginsenosides,which provides a theoretical basis for their bioactivity-guided research.