Disruption of KDM4C-ALDH1 A3 feed-forward loop inhibits sternness,tumorigenesis and chemoresistance of gastric cancer stem cells

作     者：Tingyuan Lang Jia Xu Lei Zhou Zhiqi Zhang Xinli Ma Jiayi Gu Jingshu Liu Yunzhe Li Dongyan Ding Jiangfeng Qiu 

作者机构：Ddepartment of Gynecologic OncologyChongqing University Cancer HospitalSchool of MedicineChongqing UniversityChongqingPeople's Republic of China Department of Gastrointestinal SurgeryRenji Hospital Shanghai Jiao Tong University School of MedicineShanghaiPeople's Republic of China Singapore Eye Research InstituteThe AcademiaSingaporeSingapore Department of OphthalmologyYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Ophthalmology and Visual Sciences Academia Clinical ProgramDuke-NUS Medical SchoolSingaporeSingapore Department of General SurgeryShanghai Fourth People's Hospital Affiliated to Tongji University School of MedicineShanghaiPeople's Republic of China 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第10期

页      面：2975-2977页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Science and Technology Commission of Shanghai Municipality Fund(16ZR1420500) the Chongqing Science and Technology Commission(cstc2019jscx-msxmX0174) 

主　　题：cancer Gastric Cancer 

摘      要：Dear Editor,Gastric cancer(GC)is a considerable global health burden;the median survival of advaneed GC is less than 1 year.^(1)Cancer stem cells(CSCs),a small population of cancer cells with stem cell-like properties,are the major cause of treatme nt failure,in eluding GC,2 however,the mechanisms underlying stemness maintenanee of GC stem cells(GCSCs)are still poorly understood.