Production of L-glutamate family amino acids in Corynebacterium glutamicum:Physiological mechanism,genetic modulation,and prospects

作     者：Qi Sheng Xiao-Yu Wu Xinyi Xu Xiaoming Tan Zhimin Li Bin Zhang 

作者机构：Jiangxi Engineering Laboratory for the Development and Utilization of Agricultural Microbial ResourcesCollege of Bioscience and BioengineeringJiangxi Agricultural UniversityNanchang330045China State Key Laboratory of Biocatalysis and Enzyme EngineeringSchool of Life SciencesHubei UniversityWuhan430062China 

出 版 物：《Synthetic and Systems Biotechnology》 (合成和系统生物技术（英文）)

年 卷 期：2021年第6卷第4期

页      面：302-325页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 0703[理学-化学] 0836[工学-生物工程] 071005[理学-微生物学] 10[医学] 

基　　金：This work was supported by National Natural Science Foundation of China[No.32000057] Open Funding Project of the State Key Laboratory of Biocatalysis and Enzyme Engineering(SKLBEE2019015) Jiangxi Provincial Natural Science Foundation(No.20202BAB213023) Jiangxi Province Postgraduate Innovation Special Fund Project[No.YC2020-S258] 

主　　题：L-glutamate family Amino acids C.glutamicum Regulatory mechanism Metabolic engineering Fermentation 

摘      要：L-glutamate family amino acids(GFAAs),consisting of L-glutamate,L-arginine,L-citrulline,L-ornithine,L-proline,L-hydroxyproline,γ-aminobutyric acid,and 5-aminolevulinic acid,are widely applied in the food,pharmaceutical,cosmetic,and animal feed industries,accounting for billions of dollars of market *** GFAAs have many functions,including being protein constituents,maintaining the urea cycle,and providing precursors for the biosynthesis of ***,the production of GFAAs mainly depends on microbial fermentation using Corynebacterium glutamicum(including its related subspecies Corynebacterium crenatum),which is substantially engineered through multistep metabolic engineering *** review systematically summarizes recent advances in the metabolic pathways,regulatory mechanisms,and metabolic engineering strategies for GFAA accumulation in *** and ***,which provides insights into the recent progress in L-glutamate-derived chemical production.