Targeting chaperon protein HSP70 as a novel therapeutic strategy for FLT3-ITD-positive acute myeloid leukemia

作     者：Chen Hu Fengming Zou Aoli Wang Weili Miao Qianmao Liang Ellen L.Weisberg Yinsheng Wang Jing Liu Wenchao Wang Qingsong Liu Chen Hu;Fengming Zou;Aoli Wang;Weili Miao;Qianmao Liang;Ellen L.Weisberg;Yinsheng Wang;Jing Liu;Wenchao Wang;Qingsong Liu

作者机构：Anhui Province Key Laboratory of Medical Physics and TechnologyInstitute of Health and Medical TechnologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhuiPeople’s Republic of China Hefei Cancer HospitalChinese Academy of SciencesHefeiAnhuiPeople’s Republic of China Department of ChemistryUniversity of California-RiversideRiversideCAUSA University of Science and Technology of ChinaHefeiAnhuiPeople’s Republic of China Department of Medical OncologyDana Farber Cancer InstituteHarvard Medical SchoolBostonMAUSA 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2021年第6卷第10期

页      面：2967-2970页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.81903650,81803366,81673469,81773777) the Natural Science Foundation of Anhui Province(Grant Nos.2008085MH274,1808085MH268) the China Postdoctoral Science Foundation(Grant No.2019M652057) the Postdoctoral Science Foundation of Anhui Province(Grant No.2019B300) the Frontier Science Key Research Program of CAS(Grant No.QYZDB-SSW-SLH037) the Collaborative Innovation Program of Hefei Science Center,CAS(Grant No.2019HSC-CIP011) the CASHIPS Director’s Fund(Grant Nos.BJPY2019A03,YZJJZX202011) 

主　　题：HSP70 therapeutic acute 

摘      要：Dear Editor,Approximately 25%of acute myeloid leukemia(AML)carries FLT3-ITD(internal tandem duplication)oncogenic *** FLT3 kinase inhibitors have already been successfully used in the clinic for treating FLT3-ITD-positive AML,acquired drug resistance is observed after the prolonged ***,seeking a new therapeutic strategy is still imperative for FLT3-ITD-positive AML.