Acute oral toxicity test and assessment of rhynchophylline in mice

作     者：Lanlan Hu Huijing Zhang Le Zhang Jianlin Tang 胡岚岚;张惠静;张乐;汤建林

作者机构：National Drug Clinical Trial Institutionthe Second Affiliated HospitalArmy Medical UniversityChongqing 400037China Department of Pharmaceutical Analysis and Analytical ChemistryCollege of PharmacyArmy Medical UniversityChongqing 400038China 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2021年第30卷第8期

页      面：657-665页

核心收录：

学科分类：100405[医学-卫生毒理学] 1007[医学-药学(可授医学、理学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

主　　题：Rhynchophylline Acute oral toxicity Median lethal dose Mice 

摘      要：As the main alkaloid constituent of Uncaria species,rhynchophylline has drawn extensive attention in recent years for its antihypertensive and neuroprotective ***,toxicity study of the rhynchophylline is still *** the present study,oral acute toxicity of rhynchophylline was conducted in Kunming *** mice were orally treated with 520.00,442.00,375.70,319.34 and 271.44 mg/kg of rhynchophylline for 14 *** general behavior,body weight changes,toxic reaction,and death were recorded,and histopathological analyses were *** acute toxicity was evaluated by the assessment of the median lethal dose(LD50).The acute toxicity study showed that no significant difference was found in the body weight of the mice in the control group and those in the drug ***,the mice treated with rhynchophylline showed obvious abnormal symptoms and *** median lethal dose(LD50)of orally administered rhynchophylline was 308.08 mg/*** histopathological results showed that the mice in the high-dose rhynchophylline group displayed toxic effects in the brain,liver,lung,and *** results of the current study indicated that rhynchophylline could not be taken at a high ***,our current findings provided a strong basis for further clinical investigation.