Application of extracorporeal therapies in critically ill COVID-19 patients

作     者：Zhifeng ZHOU Huang KUANG Yuexian MA Ling ZHANG Zhifeng ZHOU;Huang KUANG;Yuexian MA;Ling ZHANG

作者机构：Department of NephrologyKidney Research InstituteWest China HospitalSichuan UniversityChengdu 610041China Renal DivisionPeking University First HospitalPeking University Institute of NephrologyKey Laboratory of Renal DiseaseMinistry of Health of ChinaBeijing 100034China Department of NephrologyHospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2021年第22卷第9期

页      面：701-717页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the 1.3.5 Project for Disciplines of Excellence West China Hospital Sichuan University(Nos.2018HXFH018 and ZYGD18027) China 

主　　题：Coronavirus disease 2019(COVID-19) Critical illness Cytokine release syndrome(CRS) Acute kidney injury(AKI) Extracorporeal therapy 

摘      要：The coronavirus disease 2019(COVID-19)pandemic is a major public health event caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).COVID-19 has spread widely all over the world.A high proportion of patients become severely or critically ill,and suffer high mortality due to respiratory failure and multiple organ ***,providing timely and effective treatment for critically ill patients is essential to reduce overall *** plasma therapy and pharmacological treatments,such as aerosol inhalation of interferon-α(IFN-α),corticosteroids,and tocilizumab,have all been applied in clinical practice;however,their effects remain *** studies have shown that extracorporeal therapies might have a potential role in treating critically ill COVID-19 *** this review,we examine the application of continuous renal replacement therapy(CRRT),therapeutic plasma exchange(TPE),hemoadsorption(HA),extracorporeal membrane oxygenation(ECMO),and extracorporeal carbon dioxide removal(ECCO2 R)in critically ill COVID-19 patients to provide support for the further diagnosis and treatment of COVID-19.