High level of circPTN promotes proliferation and stemness in gastric cancer
作者机构：Department of GastroenterologyShanghai Changzheng HospitalThe Second Military Medical UniversityShanghai200001China Department of GastroenterologyShanghai First People’s HospitalShanghai200003China Department of GastroenterologyShanghai Hospital of Integrated Traditional Chinese and Western MedicineShanghai200003China
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2021年第45卷第6期
页 面：1521-1526页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：circPTN Gastric cancer Proliferation and stemness
摘 要：Increasing evidence proves that circular RNAs(circRNAs)play an important role in regulating the biological behaviors of *** central purpose of this research was to investigate the functions of circRNA in gastric *** utilization of real-time PCR was to test circPTN expression in gastric cancer *** counting colony formation assays,CCK-8 assay,and EdU assay were used to investigate *** assay was applied to investigate *** discovered that circPTN was highly expressed in gastric cancer *** expression of circPTN inhibits gastric cancer cell proliferation and *** expression of circPTN promotes gastric cancer cell proliferation and ***,we discovered that circPTN could accelerate self-renewal and increase the expression of stemness *** results of our study suggested that a high level of circPTN expression promotes the proliferation and stemness of gastric cancer cells.
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