Estimating a Reliable Cutoff Point of 1‑Propanol in Postmortem Blood as Marker of Microbial Ethanol Production
作者机构：Laboratory of Forensic Medicine and ToxicologyFaculty of MedicineSchool of Health SciencesUniversity of IoanninaIoanninaGreece Laboratory of Medical PhysicsFaculty of MedicineSchool of Health SciencesUniversity of IoanninaIoanninaGreece
出 版 物：《Journal of Forensic Science and Medicine》 (法庭科学与法医学杂志（英文）)
年 卷 期：2019年第5卷第3期
页 面：141-146页
主 题：1‑propanol blood ethanol forensic postmortem
摘 要：The interpretation of the ethanol analysis results in postmortem cases may be challenging when the origin of postmortem ethanol(antemortem ingestion or microbial production)is under *** this study,we investigated the suitability of blood 1‑propanol cutoff concentration as a reliable marker for the discrimination between“positiveand“negativefor postmortem ethanol production(PEP)autopsy blood samples by performing receiver operating characteristic(ROC)*** results indicated that a threshold 1‑propanol concentration of 0.104 mg/dL had an area under the curve of 0.90(standard deviation=0.03),sensitivity of 79%,and specificity of 91%for predicting PEP with 95%confidence *** means that the positive for PEP autopsy blood samples yield significantly differentiated PEP than approximately 90%of the *** estimated concentration of 1‑propanol is an applicable threshold(cutoff)value for autopsy blood 1‑propanol to discriminate between“positiveand“negativesamples for *** named this threshold 1‑propanol concentration(of 0.104 mg/dL)as“1‑propanol criterion.In an effort to test its applicability to postmortem cases,we evaluated blood ethanol and 1‑propanol from 222 postmortem cases *** results showed that 10%of the tested samples were positive for PEP,and only a few of them were from bodies with signs of putrefaction at *** finding indicates that PEP in a corpse could take place before the appearance of obvious *** suggest the ROC‑based calculation of the 1‑propanol cutoff concentration,at 0.104 mg/dL,as an effective method for“flaggingblood samples as positive for PEP irrespectively of the presence or not of putrefaction.
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