Epidemiology and factors predicting survival of amyotrophic lateral sclerosis in a large Chinese cohort

作     者：Ming Gao Na Liu Xue-Mei Li Liu-Wen Chao Hong-Qi Lin Yan Wang Yan Sun Chen Huang Xiao-Gang Li Min Deng Gao Ming;Liu Na;Li Xue-Mei;Chao Liu-Wen;Lin Hong-Qi;Wang Yan;Sun Yan;Huang Chen;Li Xiao-Gang;Deng Min

作者机构：Institute of Medical Innovation and ResearchPeking University Third HospitalBeijing 100191China Department of NeurologyPeking University Third HospitalBeijing 100191China Department of NeurologyAffiliated Hospital of Weifang Medical UniversityWeifangShandong 261000China Department of AnesthesiologyFuwai Central China Cardiovascular HospitalZhengzhouHenan 450000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第18期

页      面：2231-2236页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.31670987) the Beijing Natural Science Foundation(No.7192223) 

主　　题：Amyotrophic lateral sclerosis Epidemiology Clinical features Occupation Survival factors 

摘      要：Background:Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disorder associated with loss of motor *** objective was to explore the epidemiology,clinical features,and survival factors of 1809 patients with ***:We analyzed 1809 ALS patients,who were recruited from the Peking University Third Hospital from January 2005 to December *** data and disease-related parameters were ***-Meier curves were used to compare survival *** proportional hazards function and the hazard ratio were used to identify adjusted prognostic ***:The results showed that the average annual incidence in Beijing alone was 0.38 cases/100,000 person-years and the mean age of onset was 48.88±11.35(95%confidence interval[CI]:48.17–49.85)*** median survival time from onset to death/tracheostomy was 58.89±33.03(95%CI:51.46–63.84)*** the adjusted Cox proportional hazard model,age of onset,diagnosis delay,rate of disease progression(Amyotrophic Lateral Sclerosis Functional Rating Scale Revised decline[points/month]),and body mass index all had an independent effect on survival in ***:Our study provides information on epidemiology,clinical features,and survival factors of patients with ALS in *** results can be helpful in clinical practice,clinical trial design,and validation of new tools to predict disease progression.