Ultrasensitive detection of endocrine disruptors via superfine plasmonic spectral combs
作者机构：State Key Joint Laboratory of ESPCSchool of EnvironmentTsinghua UniversityBeijing 100084China Institute of Photonics TechnologyJinan UniversityGuangzhou 510632China
出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)
年 卷 期：2021年第10卷第10期
页 面：1849-1862页
核心收录：
学科分类：07[理学] 070302[理学-分析化学] 070204[理学-等离子体物理] 0703[理学-化学] 0702[理学-物理学]
基 金：This research was supported by National Key Research and Development Project(2019YFD1100505) the Key Program of National Natural Science Foundation of China(62035006) the National Natural Science Foundation of China(21976100,61975068,62005101,62011530459)
摘 要：The apparent increase in hormone-induced cancers and disorders of the reproductive tract has led to a growing demand for new technologies capable of detecting endocrine ***,a long-lasting challenge unaddressed is how to achieve ultrahigh sensitive,continuous,and in situ measurement with a portable device for infield and remote environmental *** we demonstrate a simple-to-implement plasmonic optical fiber biosensing platform to achieve an improved light–matter interaction and advanced surface chemistry for ultrasensitive detection of endocrine *** platform is based on a gold-coated highly tilted fiber Bragg grating that excites high-density narrow cladding mode spectral combs that overlap with the broad absorption of the surface plasmon for high accuracy interrogation,hence enabling the ultrasensitive monitoring of refractive index changes at the fiber *** the use of estrogen receptors as the model,we design an estradiol–streptavidin conjugate with the assistance of molecular dynamics,converting the specific recognition of environmental estrogens(EEs)by estrogen receptor into surface-based affinity bioassay for *** ultrasensitive platform with conjugate-induced amplification biosensing approach enables the subsequent detection for EEs down to 1.5×10−3 ng ml−1 estradiol equivalent concentration level,which is one order lower than the defined maximal E2 level in drinking water set by the Japanese *** capability to detect EEs down to nanogram per liter level is the lowest limit of detection for any estrogen receptor-based detection reported thus *** compact size,flexible shape,and remote operation capability open the way for detecting other endocrine disruptors with ultrahigh sensitivity and in various hard-toreach spaces,thereby having the potential to revolutionize environment and health monitoring.
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