Developmental Aspect of Decidual Patterning
Developmental Aspect of Decidual Patterning作者机构：Reproductive Medical CenterThe First Affiliated Hospital of Xiamen UniversityXiamenFujian 361003China Fujian Provincial Key Laboratory of Reproductive Health ResearchMedical CollegeXiamen UniversityXiamenFujian 361102China
出 版 物：《Reproductive and Developmental Medicine》 (生殖与发育医学（英文版）)
年 卷 期：2017年第1卷第2期
页 面：100-114页
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100211[医学-妇产科学] 10[医学]
基 金：The work incorporated in this review article was supported in parts by National Key R&D program of China(2017YFC1001402 to H.W.) the National Natural Science Foundation(81330017 and 81490744 to H.W.,81601285 to S.K.,and 31600945 to J.L.) Fujian Natural Science Foundation(2017J01071 to J.L.).
主 题：Decidualization Implantation Mouse Model
摘 要：In clinical practice,early pregnancy loss has afflicted approximately 15%–25%women of reproductive age worldwide,which is partially attributed to defects associated with the endometrium.During pregnancy,the endometrial stromal cells experience remarkable tissue remodeling and transformation,termed as decidualization,to support embryonic development,placental formation,and the maintenance of normal pregnancy in both mice and human.During this process,a series of dynamic developmental events,including rapid stromal proliferation,increased stromal cell size,enhanced angiogenesis,taken place in a highly-ordered manner under the precise regulation of steroid hormones.Meanwhile,diverse molecules exhibit spatiotemporal-specific expression pattern,implying their unique roles in decidual development.To achieve a more comprehensive understanding of these biological events and explore the underlying causes of early pregnancy disorders,this review emphasizes on the detailed developmental progression of decidual transformation and patterning as well as related pregnancy complications at the early stage of pregnancy.
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