Dysphagia,reflux and related sequelae due to altered physiology in scleroderma
作者机构：Albany Medical CollegeAlbanyNY 12208United States Department of DentistryMinistry of HealthAlexandria 21500Egypt Division of RheumatologyAlbany Medical CenterAlbanyNY 12208United States Division of GastroenterologyAlbany Medical CenterAlbanyNY 12208United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2021年第27卷第31期
页 面：5201-5218页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Systemic sclerosis Esophageal motility disorders Deglutition Deglutition disorders Gastroesophageal reflux Esophagitis
摘 要：Systemic sclerosis is a connective tissue disease that presents with significant gastrointestinal involvement,commonly in the *** is a common clinical manifestation of systemic sclerosis and is strongly related to esophageal ***,there are multiple other contributing factors in each step in the physiology of swallowing that may contribute to development of severe *** oral phase of swallowing may be disrupted by poor mastication due to microstomia and poor dentition,as well as by *** the pharyngeal phase of swallowing,pharyngeal muscle weakness due to concurrent myositis or cricopharyngeal muscle tightening due to acid reflux can cause *** esophageal phase of swallowing is most commonly disturbed by decreased peristalsis and esophageal ***,it can also be affected by obstruction from chronic reflux changes,pill-induced esophagitis,or Candida *** contributing factors to dysphagia include difficulties in food preparation and *** the anatomy and physiology of swallowing and evaluating systemic sclerosis patients presenting with dysphagia for disturbances in each step can allow for development of better treatment plans to improve dysphagia and overall quality of life.
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