Regulation of bile acid receptor activity

作     者：Yu-Jui Yvonne Wan Lili Sheng Yu-Jui Yvonne Wan;Lili Sheng

作者机构：Department of Medical Pathology and Laboratory MedicineUniversity of CaliforniaDavisSacramentoCAUSA 

出 版 物：《Liver Research》 (肝脏研究（英文）)

年 卷 期：2018年第2卷第4期

页      面：180-185页

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：This study was supported by grants funded by the USA National Institutes of Health(NIH)U01CA179582 and R01 CA222490. 

主　　题：Bile acid receptor Farnesoid X receptor(FXR) G protein-coupled bile acid receptor Takeda G protein receptor 5(TGR5) Sphingosine-1-phosphate receptor 2 (S1PR2) Acetylation Methylation Glycosylation 

摘      要：Many receptors can be activated by bile acids(BAs)and their derivatives.These include nuclear receptors farnesoid X receptor(FXR),pregnane X receptor(PXR),and vitamin D receptor(VDR),as well as membrane receptors Takeda G protein receptor 5(TGR5),sphingosine-1-phosphate receptor 2(S1PR2),and cholinergic receptor muscarinic 2(CHRM2).All of them are implicated in the development of metabolic and immunological diseases in response to endobiotic and xenobiotic exposure.Because epigenetic regulation is critical for organisms to adapt to constant environmental changes,this review article summarizes epigenetic regulation as well as post-transcriptional modification of bile acid re-ceptors.In addition,the focus of this review is on the liver and digestive tract although these receptors may have effects on other organs.Those regulatory mechanisms are implicated in the disease process and critically important in uncovering innovative strategy for prevention and treatment of metabolic and immunological diseases.