Golgi protein 73, hepatocellular carcinoma and other types of cancers
作者机构：Department of Pathology and Laboratory MedicineUniversity of California DavisSacramentoCAUSA State Key Laboratory of Medical Molecular BiologyDepartment of Physiolog
出 版 物：《Liver Research》 (肝脏研究（英文）)
年 卷 期：2020年第4卷第4期
页 面：161-167页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This study was supported bygrants funded by the USA National Institutes of Health(NIH)R01CA222490 to Y.-J.Y.Wan along with grants from the National Natural Science Foundation of China Project number 81602456 financial sup-port from the China Scholarship Council(CSC)to Y.Wang
主 题：Liver cancer Hepatocellular carcinoma(HCC) Diagnostic markers Golgi protein 73(GP73) Alpha-fetoprotein(AFP) Gamma-glutamyl transferase(GGT) Hepatitis C virus(HCV) Hepatitis B virus(HBV)
摘 要：Hepatocellular carcinoma(HCC)is one of the most common malignant tumors with a low survival *** identification of mechanisms underlying the development of HCC helps uncover cellular and mo-lecular targets for the diagnosis,prevention,and treatment of *** protein 73(GP73)level is up-regulated in HCC patients and potentially can be a therapeutic *** many studies devoted to GP73 as a marker for HCC early diagnosis,there is little discussion about the function of GP73 in HCC *** the poor response to currently available HCC therapies,a better understanding of the role of GP73 in HCC may provide a new therapeutic target for *** current paper summarizes the role of GP73 as a diagnostic marker as well as its roles in liver *** roles in other types of cancer are also discussed.
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