Protective Effect of Ginsenoside Rd on Lipopolysaccharide-Induced Acute Lung Injury through its Anti-Inflammatory and Anti-Oxidative Activity

作     者：Jv Chen Wan-Xian Fang Shao-Jin Li Shui-Xiu Xiao Hai-Jian Li Yong-Li Situ Jv Chen;Wan?Xian Fang;Shao?Jin Li;Shui?Xiu Xiao;Hai?Jian Li;Yong?Li Situ

作者机构：Department of PharmacyAffiliated Hospital of Guangdong Medical UniversityZhanjiang Guangzhou Darui Biotechnology Co.Ltd.Guangzhou Obstetrics and GynecologyShenzhen Longhua District Central Hospital Medical LaboratoryShenzhen Longhua District Central HospitalShenzhen Department of Clinical Laboratory MedicineGuangdong Second Provincial General HospitalGuangzhou College of pharmacyJinan UniversityGuangzhouChina 

出 版 物：《World Journal of Traditional Chinese Medicine》 (世界中医药杂志（英文）)

年 卷 期：2021年第7卷第3期

页      面：383-390页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Acute lung injury ginsenoside Rd inflammatory oxidative stress 

摘      要：Background:Inflammation and oxidation stress are key factors in the mechanism of acute lung injury(ALI).Therefore,suppression of the inflammatory response and oxidative stress could be a potential strategy to treat lipopolysaccharide(LPS)-induced *** Rd(Rd),a natural Ginseng extract,alleviates inflammation and oxidative stress in several diseases such as Alzheimer’s disease and cerebral ischemia,but its effect on ALI is still *** and Objectives:To explore the protective effect of Rd on LPS-induced ALI and explored associated *** and Methods:Mice were divided into five groups:A sham-operated group,a LPS-induced ALI group,and three LPS groups pretreated with Rd doses of 20,40,and 80 mg/kg,*** pathological changes of lung,collagen deposition,pulmonary edema,inflammatory cytokine,oxidative stress and the expression levels of TLR4 and NF-κB were ***:The oral administration of Rd dose dependently attenuated histopathologic changes in the lung,lung edema,pulmonary collagen deposition,protein concentration in bronchoalveolar lavage fluid(BALF),myeloperoxidase(MPO)activity,and inflammatory cell *** addition,Rd suppressed the LPS-induced inflammatory cytokines tumor necrosis factor-α,interleukin(IL)-6,and IL-1βin *** productions of oxidative stress-related enzymes(catalase,superoxide dismutase,and glutathione peroxidase)in lung tissue were significantly upregulated by Rd ***,malondialdehyde and pulmonary MPO activity was reduced in the Rd-pretreated groups when compared with LPS-induced ALI *** treatment also dose dependently suppressed LPS-induced NF-κB activation and TLR4 ***:Overall,these findings provide evidence that Rd pretreatment inhibits LPS-induced ALI through anti-inflammatory and antioxidative actions,suggesting that it could be a promising protective drug for LPS-induced ALI.